Protective role of lycopene on polychlorinated biphenyls (Aroclor 1254)-induced adult rat Sertoli cell dysfunction by increased oxidative stress and endocrine disruption, Comparative analysis of lycopene in oxidative stress, Male infertility: A critical review of pharmacologic management, Sperm Diagnostics and Selecting Healthier Spermatozoa, Ejaculatory duct obstruction in the infertile male: Experience of 7 cases at Ramathibodi Hospital. Numerous epidemiological studies have linked diets that are high in lycopene intake with a reduced risk of cancer and degenerative diseases. Many products that we purchase and consume are full of harmful chemicals that can wreak lasting havoc on our minds and bodies. One promising compound is the tomato-derived carotenoid lycopene. Up to 15 percent of couples are infertile. A new study of a small cohort of men has found that the pigment which gives the fruit its red colour, known as lycopene, could boost sperm quality, specifically around size and swimming capabilities. Because lycopene is an antioxidant, it has certain properties that help it fight against something called “free radical compounds”. We’ve mentioned there are multiple health benefits of consuming fruits like Gac that contain lycopene, particularly for men. “The antioxidant properties of lycopene have been the focus of lycopene’s action on male infertility to date,” the team say. By trying out our new powder form you can also get a significant serving of lycopene. While sunburns aren’t exclusive to men, men are statistically. ConsumerLab's tests revealed that one product contained only 60% of its listed lycopene; pills strengths ranged from 5 mg to 30 mg; and the cost to get a 10 mg dose of lycopene ranged from just 7 cents to 53 cents. Maximum improvement seems tooccur in the sperm concentration (66% cases).Patients without severe oligospermia (spermdensity >5 million/ml) may be given a trialof therapy with lycopene. Durairajanayagam D, Agarwal A, Ong C, Prashast P. Lycopene and male infertility. Lycopene is a component of human redox defence mechanism against free radicals. It is found in high concentrations in the testes and seminal plasma and decreased levels have been demonstrated in men suffering from infertility. , which are one of the primary sources of lycopene in the American diet. Whether lycopene attenuates PCBs-induced disruption in Sertoli cells or not? HCG: 500 to 1000 units IM 3 times a week for 3 weeks, then 500 to 1000 units IM 2 times a week for 3 weeks OR 4000 units IM 3 times a week for 6 to 9 months, then 2000 units IM 3 times a week for 3 months Uses:-Selected cases of hypogonadotropic hypogonadism in males Lycopene is able to reduce bad cholesterol, which can lead to heart disease. Let’s break it down. However, in the presence of the highest dose of lycopene, both the viability and osmotic-resistance of chilled spermatozoa and the DNA integrity of frozen spermatozoa were similar to those of fresh spermatozoa. In PCBs exposure, serum hormones (FSH, testosterone and estradiol), Sertoli cellular receptors (FSHR and AR) were significantly decreased whereas oxidative stress markers (H2O2 and LPO) and ER-ß expression in Sertoli cells were significantly increased. Multiple over‐the‐counter (OTC) therapies have been historically used for male fertility, including herbs, vitamins, and nutritional supplements (Crimmel et al, 2001).Because infertility affects 15% of couples trying to conceive, with male factor implicated solely or in combination with a female factor in 50% of the cases, many male patients use these therapies (Sharlip et al, 2002). And, it limits tumor growth in the prostate. No matter how you choose to incorporate lycopene into your diet, GacLife is here to support you in that! Lycopene Pronunciation ... cardiovascular disease, male infertility, osteoporosis, hypertension, neurodegenerative diseases, and inflammatory diseases. The success rate is not associated with the number of sperm abnormalities in our study. Reprod Sci 2014; 21: 89-101. The leading cause of male infertility stems from a loss of spermatozoa function, ultimately resulting in a loss of fertilization potential . With all these amazing properties of lycopene, you’re probably wondering where exactly gac fruit fits into this picture. So far, a clinical study, involving 47,365 persons, has demonstrated the reduced risk of prostate cancer following lycopene intake, and a reduction of male infertility and improvement of sperm quality using lycopene as a dietary supplement, thus increasing sperm number and viability [33,37]. Lycopene helps combat these free radicals and keeps their levels balanced in your body. This study summarizes the information about lycopene and presents the current knowledge with respect to its role in human health and disease. Once again, lycopene comes to the rescue. Lycopene is one of the most vital secret ingredients that makes Gac the magical solution for handling a wide variety of health issues. Published 26 September 2019. 2014 May-Jun; 16(3): 420–425. Early research shows that taking lycopene by mouth daily for 3 months improves sperm quality in some men with fertility problems due to unknown causes. tified as one of the causes of male infertility. Unfortunately, 30 - 50% of the etiologies of male infertility are unknown and therefore, no specific therapy can be instituted. In the long-term follow-up, 4 of 7 (57%) were able to impregnate their wives. High-quality research on lycopene alone is needed. “Oxidative stress may play a role in male infertility pathogenesis and while reactive oxygen species play a role in normal sperm function, disequilibrium of reactive oxygen species and antioxidant defence appears to be detrimental. Check out our range of products today and find what works best for you. Pregnancy rates, while higher for the surgical group, was not statistically different in both groups. Background and objectives: This study aimed to investigate the effects of tomato juice consumption on seminal plasma lycopene levels and sperm parameters in infertile men. At GacLife, we are actively working on taking these vital elements and turning them into beverages and powders that can be consumed to receive all the things we need to stay ahead of these major health concerns. . The antioxidant properties help balance free radical activity in the body and in doing so, may offer protection against certain diseases, keep bones strong and healthy, and help eyesight by helping delay or prevent cataracts, macular degeneration, and other age-rela… Human trials have reported improvement in sperm parameters and pregnancy rates with supplementation of 4-8 mg of lycopene daily for 3-12 months. considerably in the dosage or combinations used, as well as outcome measures. Lycopene therapy in idiopathic male infertility – a preliminary report Narmada P. Gupta & Rajeev Kumar Department of Urology, All India Institute of Medical Sciences, Ansari Nagar, 110029,New Delhi, India Abstract. Sertoli cell functional proteins such as connexin 43, transferrin and androgen-binding protein expressions and the level of lactate were significantly decreased. Lycopene (molecular formula: C40H56) is a linear, unsaturated hydrocarbon carotenoid, the major bright red pigment, a phytochemical found in fruits such as tomatoes and other red fruits such as papaya, pink grapefruit, apricots, red oranges, watermelon, rosehips and guavas 3).Lycopene is the most common carotenoid in the human body and is one of the most potent … Its antioxidant effect includes a considerable reactive oxygen species scavenging activity, which allows lycopene to prevent lipid per oxidation and DNA damage. The good news is that there’s a way to combat these issues! Free full text Asian J Androl . Thus, the aim of this study was to evaluate the effect of lycopene supplementation on spermatogram and seminal oxidative stress. Impact of lycopene on epididymal androgen and estrogen receptors' expression in polychlorinated biphenyls-exposed rat. In addition, the city environments are overloaded with extra free radicals courtesy of sources like industrial pollution, motor vehicles and smoking. In conclusion, the presence of lycopene in the extender improved the survival of turkey spermatozoa after liquid-storage and protected DNA integrity against cryodamage. In young men, taking the recommended dose of lycopene increased sperm mobility and healthy shaped sperm by 40%. Since the compound also cuts the risk of cancer of the prostate, it can further promote reproductive health (as the prostate gland makes seminal fluid) . Maximum improvement seems tooccur in the sperm concentration (66% cases).Patients without severe oligospermia (spermdensity >5 million/ml) may be given a trialof therapy with lycopene. Ejaculatory duct obstruction is a treatable cause of male infertility. The man in the Harvard study with the greatest protection against cancer consumed at least 6.5 mg per day. Hence, there is not agreement about the dosage. Hence, there is a need to increase the dietary intake of an effective antioxidant such as lycopene. Lycopene is a naturally occurring chemical that gives fruits and vegetables a red color. May Treat Infertility. The top sources for lycopene include: Whichever food source you choose, getting a healthy dose of lycopene is the first step in taking care of your health! The administration of these molecules in the treatment of male infertility (alone or in combination) is, therefore, a rational and effective therapeutic strategy. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. … Excessive generation of reactive oxygen species (ROS) containing free oxygen radicals has been iden-tified as one of the causes of male infertility. pregnancy rate per cycle is obtained with 5.10(6) to 10.10(6) inseminated. That’s enough to help reduce your sunburn, reduce cancer risks, combat heart disease, lower bad cholesterol, and a whole host of other things as well. “ A 2000 study in India examined 30 men with idiopathic infertility. However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene as a treatment for male infertility. In young men, taking the recommended dose of lycopene increased sperm mobility and healthy shaped sperm by 40%. Lycopene and male infertility Damayanthi Durairajanayagam1,2, Ashok Agarwal 1, Chloe Ong , Pallavi Prashast Excessive amounts of reactive oxygen species (ROS) cause a state of oxidative stress, which result in sperm membrane lipid peroxidation, DNA damage and apoptosis, leading to decreased sperm viability and motility. The recommended dose of lycopene is 16mg per day, but it can be tough to get that much lycopene in your diet. L- Carnitine plays important role in the formation of sperm. However, clinical benefits should not be achieved at high dose, since the evidence of calcium chelator activity of l ‐carnitine that may determine cell damage and decrease in serum calcium. However, further detailed and extensive research is still required to determine the dosage and the usefulness of lycopene for male infertility treatment . Oral Lycopene therapy seems to have a role in the management of idiopathic male infertility. All antioxidants have shown a role in destroying free radicals and thereby reducing the damage to all cells in the body. Lycopene inhibits free radical damage to LDL cholesterol with its antioxidant action preventing oxidation to LDL cholesterol. The body obtains antioxidants from many of the foods that comprise a healthy diet however many people fail to eat enough of these recommended foods. However, spermatozoa chilled in lycopene-enriched extenders showed significantly lower malonaldehyde levels than those chilled without lycopene, while the addition of lycopene to the freezing medium served to maintain the lipid peroxidation levels observed in fresh semen. Human trials have reported improvement in sperm parameters and pregnancy rates with supplementation of 4-8 mg of lycopene daily for 3-12 months. Varicocele: Clinical or surgical treatment? These results are analogous to those obtained in an operated group of clinical varicoceles. A new study of a small cohort of men has found that the pigment which gives the fruit its red colour, known as lycopene, could boost sperm quality, specifically around size and swimming capabilities. The recommended daily intake of lycopene is 6 to 30 milligrams. Its use in the treatment of male infertility is based on its free radical scavenging abilities. Gac fruit is a unique fruit from Vietnam that is packed with vital elements: vitamins and nutrients; and most especially, in reference to the above, the carotenoid Lycopene. Methods and study design: Subjects were male infertility patients with poor sperm concentration (<20×10 6/mL) and/or motility (<50%). Continued improvements appeared to be evident for up to at least 6 months of administration." Men are struggling with fertility issues, low sperm count, and prostate cancer, which can all be devastating for those involved, especially when trying to build a family. Lycopene is a type of carotenoid, or plant-based pigment, that gives tomatoes, pink grapefruit and watermelon their red color. Lycopene is believed to have antioxidant benefits and has been studied for use in infertility. [Intra-uterine inseminations with hyperstimulation in male infertility], Renal and Gonadal Venography in Male Infertility. J Nutr 1997;127:1833-7. An extensive literature search was performed using the search engines: Pubmed, Science-direct, Ovid and Scopus. Contraception, Fertilité, Sexualité (1992). The medical treatment showed to be effective in elective cases. From the book Milestones in Medicine: L-carnitine & acetylcarnitine in male infertility: "These positive effects of both L-carnitine and acetylcarnitine on sperm quality were observed after at least 2 months of use, consistent with the 74-day sperm maturation cycle. Lycopene, as an antioxidant, reduces oxidative stress. 4. The top sources for lycopene include: Gac (70 times more lycopene than any other fruit or vegetable) The results showed that there was an improvement in all the spermogram parameters in both groups. The spermograms of all the patients reported sperm counts, percentage of general motility, percentage of grade III motile sperm (rapid and directional movements) and percentage of oval forms, before and after the treatment. 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