The protective role of skin lycopene is not only limited to ultraviolet radiation-induced skin erythema, premature skin aging (skin inelasticity, coarse wrinkles, skin pigmentation) but may also extend in the prevention and management of skin cancer3,4. Grabowska M, Wawrzyniak D, Rolle K, Chomczynski P, Oziewicz S, JurgaS, Barciszewski J. Crit Rev Food Sci Nutr. Accessed May 25, 2012. Some of these benefits can be gained by topical application. Written By Gary Goldfaden, MD And Robert Goldfaden. Lycopene may help increase your skin’s defense against sunburns and damage caused by UV rays. Chemistry and biotechnology of carotenoids. However, the lycopene level in corneocytes from the skin surface was greater in young volunteers than in middle-aged volunteers. 1995;125(7):1854–1859. 2016;2016:8214631. New research on lycopene, a unique carotenoid, has shown it has an ability to defend against some of the factors of skin aging. At an age when osteoporosis becomes more common, lycopene can help reduce risk for hip fracture in postmenopausal women. Rizwan M, Rodriguez-Blanco I, Harbottle A, Birch-Machin MA, Watson REB, Rhodes LE. Frontiers in Pharmacology. However, the fat soluble nature and relatively small molecule size of this powerful plant nutrient make it easily absorbed when applied topically in a cream or lotion. bioflavanoids) that help promote skin health and general health. Studies indicate that topically applied lycopene defends against skin aging by helping to stabilize DNA structure in the nucleus of skin cells, enhancing skin-cell signaling and function, and inhibiting enzymatic activity involved in collagen breakdown. Topical application of antioxidants, including polyphenols, has been scientifically shown to provide protection from sun-induced damage, slow down skin aging, reduce inflammation, and ultimately improve skin appearance. “Tomatoes act as an astringent and can reduce the appearance of … Scientifically reviewed by: Dr. Vanessa Pavey, ND, on July 2020. Vitamin C in beets also prevents dry skin and boosts collagen synthesis. Nutrition Research. Lycopene content of tomatoes and tomato products. Lifestyle modification of the masses towards healthy foods has led to increased dietary intake of lycopene that directly coincides with the presence of lycopene in the skin. Molecular Nutrition and Food Research. J Nutr Biochem. Protective effect of total carotenoid and lycopene intake on the risk of hip fracture: a 17-year follow-up from the Framingham Osteoporosis Study. Squalene and lycopene reduce sagginess, improve elasticity and lift and firm the skin. Tomato paste rich in lycopene protects against cutaneous photodamage in humans in vivo: a randomized controlled trial. A recent study by Peytaev IM and colleagues1 examined the age-dependent presence of lycopene on the skin surface and the serum. Thus, increased intake of these lycopene-rich foods may have beneficial effects not only for the skin but on the overall health. 31-33 Polyphenols are a dynamic group of approximately 8,000 organic compounds that are widely distributed in the plant kingdom. The powerful antioxidant properties of lycopene fight free radicals and oxidative stress. Ribaya-Mercado JD, Garmyn M, Gilchrest BA, Russell RM. 2005; 135(3):592-7. The skin, also a lipid-rich organ, is likely to benefit from high antioxidant activity of lycopene. †2020 Consumer Satisfaction, Rated #1 Catalog/Internet Merchant. 2003 Oct;41(10):1399-407. Studies indicate that topically applied lycopene defends against skin aging by helping to stabilize DNA structure in the nucleus of skin cells, enhancing skin-cell signaling and function, and inhibiting enzymatic activity involved in collagen breakdown. Other potential anticancer effects of lycopene are observed in lung cancer, breast cancer, colorectal cancer, gastric cancer, pancreatic cancer and ovarian cancer8-13. 2008;42(1):94-102. Di Mascio P, Kaiser S, Sies H. Lycopene as the most efficient biological carotenoid singlet oxygen quencher. 10. Skin Lycopene Is Destroyed Preferentially over β-Carotene during Ultraviolet Irradiation in Humans. Wrinkles. Some of the fruits and vegetables that are known to be rich in lycopene are tomatoes, pink grapefruit, papaya, wolfberry, and goji. Holick CN, Michaud DS, Stolzenberg-Solomon R, Mayne ST, Pietinen P, Taylor PR, Virtamo J, Albanes D. Dietary carotenoids, serum beta-carotene, and retinol and risk of lung cancer in the alpha-tocopherol, beta-carotene cohort study. The topical application of lycopene was found to reverse the reduction of PCNA caused by UVB exposure to a significant degree. 2004; 13(11 Pt 1):1772-80. Han GM, Meza JL, Soliman GA, Islam KM, Watanabe-Galloway S. Higher levels of serum lycopene are associated with reduced mortality in individuals with metabolic syndrome. Available at: http://www.tandfonline.com/doi/abs/10.1207/s15327914nc4702_11#preview. Shi J, Le Maguer M. Lycopene in tomatoes: chemical and physical properties affected by food processing. 2017;26(1):65–71, Lim S, Hwang S, Yu JH, Lim JW, Kim H. Lycopene inhibits regulator of calcineurin 1-mediated apoptosis by reducing oxidative stress and down-regulating Nucling in neuronal cells. In vivo and in vitro studies have also supported the cardiovascular protective role of lycopene through antioxidative, anti-inflammatory, antihypertensive, antiplatelet, cardioprotective, antiatherosclerotic, antiobesity and lipid-lowering mechanisms14. Huang CS, Fan YE, Lin CY, Hu ML. Oxidative stress breaks down collagen, hinders skin’s natural repair process and triggers inflammation—and you see these as fine lines, wrinkles, loose skin, acne breakouts and a blotchy skin tone. It may help improve the health and appearance of your skin. Science continues to evolve, and new research is published daily. Tomatoes and tomato products not only supply vitamin A but lycopene, the pigment contributing to their luscious red color. Available at: http://www.smartskincare.com/treatments/topical/lycopene.html. Rao AV, Rao LG. "A 2012 study showed that combining topical and oral doses of astaxanthin can help to smooth wrinkles, make age spots smaller, and help maintain skin moisture." Topical Lycopene Improves Skin Cellular Function. 2. Biomed Chromatogr. Voskuil DW, Vrieling A, Korse CM, Beijnen JH, Bonfrer JM, van Doorn J, Kaas R, Oldenburg HS, Russell NS, Rutgers EJ, Verhoef S, van Leeuwen FE, van’t Veer LJ, Rookus MA. Shop our collection of natural skin care products sourced from all over the world. Pycnogenol® French maritime pine bark extract is widely used in topical and oral applications for various dermatological indications. 2007;10(1-2):51-8. (2, 3) Unlike other vitamins, skin derives more of its benefits from vitamin E better through topical treatments than through oral supplements. Journal of Bone and Mineral Research. 1999;61:283-310. Pharmacol Res. 11. 2003 Oct;83(4):1359-400. 8. Other Potential Benefits Topical use of vitamin K may also treat rosacea, a chronic, inflammatory skin condition characterized by redness and pimples on the face. In one study, postmenopausal supplementation with lycopene showed reduced oxidative stress parameters as well as the bone resorption marker N-telopeptide of Type I collagen (NTx) which is linked to osteoporosis. 2017;61(5). Oral Health and Preventive Dentistry. This salt may also be used for purposes not listed in this medication guide. 7. Unfortunately, it is mostly deposited in fat-rich organs like your adrenal glands, colon, and liver.5,6 In the end, only a small fraction of the lycopene you eat ever reaches your skin. What are the benefits of lycopene ? DMAE helps to tighten skin and reduce sagging, improve firmness and elasticity, smooth lines and wrinkles, and brighten the skin. International Journal of Cancer. In fact, a study conducted by the Department of Dermatology at the Mount Sinai School of Medicine, examined topically-applied lycopene's ability to defend against the harmful effects of UVB radiation. American Journal of Clinical Nutrition. 2001; 94(1):128-34. Efficacy of lycopene in the treatment of gingivitis: a randomised, placebo-controlled clinical trial. Oxidative Medicine and Cellular Longevity. The Journal of Nutrition. In the substudy involving 15 middle-aged volunteers, a significant increment of the lycopene concentration in the serum and skin were observed after supplementation of 7 mg/day lycopene for a period of 2-weeks and 4-weeks1. Nutritional Neuroscience. Recently, the Department of Dermatology at the Mount Sinai School of Medicine investigated the protective effects of topically applied lycopene against the photodamage seen in skin exposed to ultraviolet (UVB)-irradiation; the radiation that is responsible for sunburn. 5. Grapefruit is rich in natural ingredients that nourish and protect the skin, including vitamins A, C and E and antioxidants. Moreover, because lycopene is especially effective in tissues with high fat content, the lipid-rich environment of the skin provides a very receptive target for its potent anti-aging benefits.7, Lycopene's powerful antioxidant action and ability to defend your skin against UV radiation are due in large part to its unique molecular design, which is responsible for lycopene's red appearance and its ability to block UV light. British Journal of Dermatology. Lycopene also has compelling neurological benefits. But grapefruit is different from other citrus fruits because it has lycopene, a known cancer-fighting chemical. Accessed May 25, 2012. 13. Lycopene is not only found in the skin but is irregularly distributed in other tissues of the body, such as testes, adrenals, prostate, liver, breast, pancreas, kidney, lungs, colon, ovary and stomach6. Detailed information related to Lycopene Topical's uses, side-effects, reviews, questions, interactions, and precautions is as follows: 2002; 156(6):536-47. Lycopene is a carotenoid naturally found in tomatoes and tomato products, carrots, watermelons, papaya, apricots, pumpkin, pink grapefruits, pink guavas, rosehips and sweet potatoes6,22. All Contents Copyright ©2021 Life Extension, Request FREE issue of Life Extension Magazine®, Website & Technology Accessibility Statement, An error on our end has caused the item you were trying to add to your cart to fail, please try again or call, Chemistry Panel & Complete Blood Count (CBC), http://www.smartskincare.com/treatments/topical/lycopene.html, http://www.tandfonline.com/doi/abs/10.1207/s15327914nc4702_11#preview, Topical Lycopene Improves Skin Cellular Function. Cramer DW, Kuper H, Harlow BL, Titus-Ernstoff L. Carotenoids, antioxidants and ovarian cancer risk in pre- and postmenopausal women. Food and Function. Physiol Rev. Food Chem Toxicol. Saw palmetto (Serenoa repens) is a small palm tree native to Florida and other areas of the southeastern United States.Today, saw palmetto is one of the most popular and best herbal DHT blockers in the country and is available in many forms including powders and extracts. Lycopene also reported to have protective roles in gingivitis and bleeding, osteoporosis, mental disorders, and asthma15-18. After ingestion, lycopene is eventually released into your lymphatic system and distributed throughout your whole body. 2019;10(6):3090-3102. Lycopene's ability to enhance connectivity and communication between cells can noticeably improve your skin's texture by aiding cellular functions that are essential to keeping your skin looking young. Food Science and Nutrition. So, you will have younger-looking skin for years. As such, we have a more recent article on this topic: Retinol Blend Reverses Skin Aging. 12 White, Thomas W.; Paul, David L. Genetic diseases and gene knockouts reveal diverse connexin functions. Oregon State University found that both dietary and topical use of vitamin C … 1999;19(2):305–323. Furthermore, lycopene may offer beneficial effects on male infertility, Down’s syndrome and Alzheimer’s disease19,20. Shi J, Qu Q, Kakuda Y, Yeung D, Jiang Y. There are two major types of ultra-violet (UV) radiation that reach us from the sun: UV-A penetrates deep into the skin. What are the benefits of using skincare and cosmetics that contain topical lycopene, plant extracts, vitamins, and minerals? 2010 Feb;24(2):154-9. Lycopene can benefit any skin type, but works especially well for sensitive and aging skin. A meta-analysis of 26 studies with 563,299 participants indicated an association of a lower risk of prostate cancer with higher lycopene supplementation and circulating concentrations7. Lycopene may also strengthen your skin by inhibiting the activity of enzymes involved in the destruction of collagen.14 This reaction breaks down the peptide bonds in the collagen fibers of your skin, resulting in gradual loss of integrity and the appearance of sags and wrinkles. Cancer Epidemiology, Biomarkers and Prevention. The ability of lycopene to block UV light is an additional benefit for the skin. More information at www.ConsumerLab.com/survey. Free Radical Research. 1989;274(2):532–538. Mozos I, Stoian D, Caraba A, Malainer C, Horbańczuk JO, Atanasov AG. Nutrition Research. Vrieling A, Voskuil DW, Bonfrer JM, Korse CM, van Doorn J, Cats A, Depla AC, Timmer R, Witteman BJ, van Leeuwen FE, Van’t Veer LJ, Rookus MA, Kampman E. Lycopene supplementation elevates circulating insulin-like growth factor binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer. Yuan JM, Ross RK, Gao YT, Qu YH, Chu XD, Yu MC. The Journal of Nutrition. 2004;44:559—73. 2008; 60(3):342-53. Though lycopene's sun protection is only equivalent to approximately SPF-3 and isn't adequate sun protection by itself, it is still a valuable added benefit for your skin.8. Topical application of lycopene combats age-causing free radicals and assists in metabolic functions related to growth and repair. © Copyright 2021 Suntory Beverage & Food Asia Pte Ltd. Petyaev IM, Pristensky DV, Morgunova EY, Zigangirova NA, Tsibezov VV, Chalyk NE, Klochkov VA, Blinova VV, Bogdanova TM, Iljin AA, Sulkovskaya LS, Chernyshova MP, Lozbiakova MV, Kyle NH, Bashmakov YK. 2009;24(6):1086-94. 2018;9:521. When compared to other antioxidants, such as vitamin E, lycopene is a more potent scavenger of the free radicals that contribute to aging and chronic disease.10 Due to the fact that lycopene is concentrated in your cell membranes, its free-radical scavenging ability plays a vital role in preventing oxidative damage to the membrane lipids, thereby influencing the thickness, strength, and fluidity of your membranes.10 Because these cell membranes are the gatekeepers of your cells, allowing nutrients to be absorbed, preventing toxins from entering, and facilitating the removal of waste products, maintaining the health and integrity of your cell membranes is a key factor in the prevention of aging. (1) It helps the skin look younger by boosting collagen production and in turn reducing the appearance of fine lines, wrinkles and age spots. Theoretically, lycopene's ability to regulate cell-to-cell junctions might provide an additional benefit of improving skin texture. Li Y, Zhang J. Serum concentrations of antioxidant vitamins and carotenoids are low in individuals with a history of attempted suicide. Lycopene's ability to enhance connectivity between cells may noticeably improve your skin's texture by aiding cellular functions that are essential to keeping your skin looking young. Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept. Plasma membrane channels formed by connexins: their regulation and functions. Topical application of lycopene combats age-causing free radicals and assists in metabolic functions related to growth and repair. Effects of lycopene on the insulin-like growth factor (IGF) system in premenopausal breast cancer survivors and women at high familial breast cancer risk. Namitha KK, Negi PS. Asia Pacific Journal of Clinical Nutrition. Ratings based on results of the 2020 ConsumerLab.com survey of supplement users. Lycopene presence in facial skin corneocytes and sebum and its association with circulating lycopene isomer profile: Effects of age and dietary supplementation. With ingredients such as vitamin C, lycopene, and various plant extracts, natural skincare products aim to effectively target the signs of aging we all strive to fight against. The same study also revealed that UVB radiation depleted an important substance in your skin known as PCNA (proliferating cell nuclear antigen), which is vital for DNA synthesis and cell repair. Chen P, Zhang W, Wang X, Zhao K, Negi DS, Zhuo L, Qi M, Wang X, Zhang X. Lycopene and Risk of Prostate Cancer: A Systematic Review and Meta-Analysis. "Lycopene is present in fruits and vegetables to help prevent damage caused by light," says Amy Hart, product development manager for Yes To. Lopes LB, Reed R. A simple and rapid method to assess lycopene in multiple layers of skin samples. It should be noted that eating raw tomatoes provides only a small amount of bioavailable lycopene.4 This is because the lycopene in raw tomatoes is tightly bound to indigestible fiber that prevents much of the nutrients from being absorbed by your body.5 On the other hand, cooked tomato products such as tomato paste or tomato sauce, are a much better source of dietary lycopene.5 As far as the health of your skin is concerned, even eating cooked tomatoes may not deliver sufficient lycopene to your skin. Besides protecting your skin cells from free radical damage and enhancing certain aspects of cell metabolism, lycopene also appears to produce its beneficial effects by improving the operation of cell-to-cell junctions.11 Also known as gap junctions, they coordinate cellular behavior by directly connecting the cytoplasm of two cells so that molecules and ions can pass freely between them.12,13 Gap junction communication can be found in all the different tissues of your body, with skeletal muscle and mobile cell types like sperm or red blood cells being the only exceptions.13 Gap junctions are particularly important to your skin because it is highly dependent upon intercellular communication for vital metabolic processes related to growth and reproduction. After ingestion, lycopene 's ability to regulate cell-to-cell junctions might provide an additional benefit the., also a lipid-rich organ, is likely to benefit from high antioxidant activity of involved! 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